Electrolyte imbalance, hyperkalemia, hypochloremic alkalosis, hypokalemia, hyponatremia, anorexia, constipation, diarrhea, dizziness, GI irritation, headache, muscle cramps, orthostatic hypotension, photosensitivity, sexual function impairment, agranulocytosis, allergic dermatitis, allergic reaction, anaphylaxis, cholecystitis, gout, hepatic function impairment, hives, hyperuricemia, itching, jaundice, pancreatitis, shortness of breath, skin rash, thrombocytopenia.
Interactions
Concomitant use of amiloride with ACE inhibitors may increase the risk of hyperkalemia. Thiazide diuretics co-administered with alcohol, barbiturates, or narcotics can potentiate orthostatic hypotension. Hydrochlorothiazide can reduce the effect of antidiabetic drugs. Co -administration of thiazide with other antihypertensive drugs provides an additive effect or potentiation. Cholestyramine and colestipol resins reduce the absorption of hydrochlorothiazide.
